Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
October 1, 1987Journal of VirologyOpen Access

Proteolytic processing of foot-and-mouth disease virus polyproteins expressed in a cell-free system from clone-derived transcripts

View Full Paper
Ask AI
Bookmark
Share

Population

Cell-free system expressing foot-and-mouth disease virus type A12 genome cDNA plasmids

Design

Preclinical

Authors

VVVikram N. VakhariaUniversity of Maryland, Baltimore CountyMDM A DevaneyPlum Island Animal Disease CenterDMD. M. MooreUniversity of Florida

Discussion

Loading...

Member takes

Implication

Elucidates FMDV protease specificities in vitro; leaves open translation to pathogenesis or antivirals pending in vivo studies.

Structured PICO

P
Population
Cell-free system (rabbit reticulocyte lysates) expressing foot-and-mouth disease virus (FMDV) type A12 genome cDNA plasmids
I
Intervention
Expression of FMDV gene products to study the function of putative proteases 3C and leader (L)
O
Outcome
Proteolytic processing of FMDV polyproteins

The study elucidates the specific roles of the leader (L) and 3C proteases in the proteolytic processing of foot-and-mouth disease virus polyproteins.

Cite This Study

Vakharia et al. (1987) studied this question.

synapsesocial.com/papers/6a6f57e5660549caf2c3e69bhttps://doi.org/10.1128/jvi.61.10.3199-3207.1987
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Implications of the picornavirus capsid structure for polyprotein processing.1987 · 188 citations
  2. 2Encephalomyocarditis virus 3C protease: efficient cell-free expression from clones which link viral 5' noncoding sequences to the P3 region1986 · 121 citations
  3. 3Colony hybridization: a method for the isolation of cloned DNAs that contain a specific gene.1975 · 3,479 citations
  4. 4Protein processing map of poliovirus1984 · 125 citations
  5. 5Proteins Induced in BHK Cells by Infection with Foot-and-Mouth Disease Virus1975 · 12 citations