Key result
This review summarizes advances in understanding adipose tissue development, emphasizing embryonic patterning of depot-specific adipocyte lineages and in vivo adipocyte differentiation.
Why the study?
Recent research has focused on elucidating the ontogenetic basis of adipose form and function across anatomically distinct depots that mediate energy homeostasis.
This review summarizes advances in understanding adipose tissue development, focusing on embryonic patterning of depot-specific adipocyte lineages and in vivo adipocyte differentiation.
Advances in adipose ontogeny extend developmental insights; leaves open cardiometabolic translation.
Adipose tissue is composed of anatomically distinct depots that mediate several important aspects of energy homeostasis. The past two decades have witnessed increased research effort to elucidate the ontogenetic basis of adipose form and function. In this Review, we discuss advances in our understanding of adipose tissue development with particular emphasis on the embryonic patterning of depot-specific adipocyte lineages and adipocyte differentiation in vivo. Micro-environmental cues and other factors that influence cell identity and cell behavior at various junctures in the adipocyte lineage hierarchy are also considered.
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Sebo et al. (2019) conducted a review in Adipose tissue development. This review summarizes advances in understanding adipose tissue development, emphasizing embryonic patterning of depot-specific adipocyte lineages and in vivo adipocyte differentiation.
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