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Highlights the debate on whether to switch from oral to inactivated polio vaccine before ending immunization.
The World Health (WHO) has implemented a plan to eradicate poliovirus that is widely viewed as having made enormous progress. If all goes as planned, polio will be eradicated on this planet by the year 2003. However, there is a debate, as highlighted in a pair of Policy Forums in this issue, over when vaccination against polio can be stopped. Dove and Racaniello believe that the reliance of the WHO on the live Sabin oral polio virus vaccine (OPV) means that there will be a continuing threat of release of potentially pathogenic virus into the environment. They are also concerned that the planned destruction of all wild-type polio stocks will not be possible. They recommend a switch to the inactivated polio vaccine. In response, Hull and Aylward set out the reasons for thinking that a switch from the OPV is not necessary and describe the studies being sponsored by the WHO to determine how and when immunization can safely be ended.
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Hull et al. (1997) studied this question.
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