Why the study?
Does intranasal inoculation with inactivated poliovaccine induce a secretory antibody response in nasal secretions?
Population
Subjects receiving intranasal inoculation of inactivated poliovaccine
Design
Other
Follow-up
Up to 3 to 4 months after primary series
Authors
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Local secretory responses to intranasal antigens merit exploration; leaves open effects on live attenuated vaccine replication or infection risk.
Does intranasal inoculation with inactivated poliovaccine induce a secretory antibody response in nasal secretions?
Intranasal inoculation of inactivated poliovaccine induces a local secretory γA antibody response in nasal secretions without a significant serum response, which may depress local replication of live attenuated virus.
Ogra et al. (1969) studied this question.
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