The study provides molecular evidence of the endemic cocirculation and evolution rate of subgenotype B1 CVA16 in China.
Informs CVA16 surveillance in China; leaves open comparative dynamics with HEV71 for clinical impact.
The molecular epidemiology of CVA16 in China between 1999 and 2008 reflects a pattern of endemic cocirculation of clusters B1a and B1b within subgenotype B1 viruses. The annual evolution rate of CVA16 was estimated as approximately 0.91 x 10(-2) substitutions per synonymous nucleotide/year and is slightly lower than that of HEV71.
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Zhang et al. (2009) studied this question.
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