Key result
Prevalent genogroups of CA16 and EV71 isolates shifted over time, but amino acid variations in the VP1 region were small, indicating outbreaks likely depend on accumulating immunologically naive children rather than viral antigenic changes.
Population
203 pediatric patients with hand, foot, and mouth disease, aseptic meningitis, or encephalitis in Toyama…
Design
Other
Authors
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HFMD outbreaks may recur via naive pediatric cohorts; hypothesis-generating for immunity-focused surveillance over antigenic monitoring.
Observational (n=203)
Yes
Large outbreaks of HFMD occurring at intervals of several years appear to depend on the accumulation of immunologically naive children rather than significant viral antigenic changes in the VP1 region.
Iwai et al. (2009) conducted an observational in Hand, foot, and mouth disease (HFMD) (n=203). Coxsackievirus A16 and Enterovirus 71 infection was evaluated on Genetic diversity and genogroup changes of the complete VP1 region of CA16 and EV71. Prevalent genogroups of CA16 and EV71 isolates shifted over time, but amino acid variations in the VP1 region were small, indicating outbreaks likely depend on accumulating immunologically naive children rather than viral antigenic changes.
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