November 9, 2006Journal of Clinical MicrobiologyOpen Access

Genetic Diversity of Coxsackievirus A16 Associated with Hand, Foot, and Mouth Disease Epidemics in Japan from 1983 to 2003

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Population

178 coxsackievirus A16 strains associated with hand, foot, and mouth disease epidemics

Authors

MHMitsuaki HosoyaFukushima Medical University YKYukihiko KawasakiFukushima Medical University MSMasatoki SatoFukushima Medical University

Discussion

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Implication

CV-A16 genetic shifts may underlie repeated HFMD outbreaks; leaves open whether phylogenetic monitoring improves epidemic prediction.

Structured PICO

Population

178 coxsackievirus A16 (CV-A16) strains associated with hand, foot, and mouth disease (HFMD) epidemics (129 from Fukushima, Japan, from 1983 to 2003, and 49 from other areas of Japan and China)

Intervention

Phylogenetic analysis based on VP4 sequences

Outcome

Genetic diversity and phylogenetic relation of CV-A16 strains

Repeated outbreaks of CV-A16-related HFMD in Japan were caused in part by the introduction of genetically changed strains.

Cite This Study

Hosoya et al. (2006) studied this question.

synapsesocial.com/papers/6a6f5f7426a7f98052dc0ccb https://doi.org/10.1128/jcm.00718-06

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Genetic Diversity of Coxsackievirus A16 Associated with Hand, Foot, and Mouth Disease Epidemics in Japan from 1983 to 2003

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Genetic Diversity of Coxsackievirus A16 Associated with Hand, Foot, and Mouth Disease Epidemics in Japan from 1983 to 2003

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider