Key result
Bovine lactoferrin inhibited enterovirus E replication in MDBK cells, reducing viral titres by 1-1.1 log and intracellular viral RNA levels by up to 75%.
Why the study?
There is no specific treatment for enterovirus infections in humans or animals, prompting evaluation of the in vitro antiviral effect of bovine lactoferrin against enterovirus E.
Does bovine lactoferrin inhibit Enterovirus E replication in MDBK cells?
Does bovine lactoferrin inhibit Enterovirus E replication in MDBK cells?
Bovine lactoferrin demonstrates in vitro antiviral activity against Enterovirus E by reducing viral replication and intracellular RNA levels in MDBK cells.
Bovine lactoferrin shows in vitro activity vs EV-E; leaves open translation to in vivo efficacy or clinical use.
Enterovirus E (EV-E), a representative of the Picornaviridae family, endemically affects cattle across the world, typically causing subclinical infections. However, under favorable conditions, severe or fatal disorders of the respiratory, digestive, and reproductive systems may develop. There is no specific treatment for enterovirus infections in humans or animals, and only symptomatic treatment is available. The aim of this study was to determine the in vitro antiviral effect of bovine lactoferrin (bLF) against enterovirus E using virucidal, cytopathic effect inhibition, and viral yield reduction assays in MDBK cells. The influence of lactoferrin on the intracellular viral RNA level was also determined. Surprisingly, lactoferrin did not have a protective effect on cells, although it inhibited the replication of the virus during the adsorption and post-adsorption stages (viral titres reduced by 1-1.1 log). Additionally, a decrease in the viral RNA level in cells (by up to 75%) was observed. More detailed studies are needed to determine the mechanism of bovine lactoferrin effect on enterovirus E. However, this highly biocompatible protein ensures some degree of protection against infection by bovine enterovirus, which is particularly important for young animals that receive this protein in their mother's milk.
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Wróbel et al. (2022) studied Enterovirus E infection. Bovine lactoferrin was evaluated on Viral replication and intracellular viral RNA level. Bovine lactoferrin inhibited enterovirus E replication in MDBK cells, reducing viral titres by 1-1.1 log and intracellular viral RNA levels by up to 75%.
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