What is the clinical evidence from this study?

Study design: Other. Population: Acute respiratory infection (n=4). Intervention: Bovine Enterovirus (EV-F) infection. Primary outcome: Identification of the causative pathogen.

August 12, 2013PLoS ONEOpen Access

Discovery of a Bovine Enterovirus in Alpaca

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Key result

A novel bovine enterovirus (Enterovirus F, strain IL/Alpaca) was identified as the potential cause of a fatal acute respiratory infection outbreak in an Illinois alpaca herd.

Authors

SMShasta D. McClenahanCenter for Biologics Evaluation and Research GSGail ScherbaUniversity of Nebraska–Lincoln LBLuke B. BorstNorth Carolina State University

Discussion

Member takes

Implication

Alerts veterinarians to novel pathogen risk in alpaca outbreaks; leaves open causality, transmission, and surveillance needs.

PICO

Population

4 alpacas aged 1.5 to 14 years from a 32-animal herd in Illinois that died of a severe acute respiratory infection.

Exposure / Comparator

Bovine Enterovirus (EV-F) infection

Primary Outcome

Identification of the causative pathogen

Limitations

Experiments did not fulfill Koch's postulates to definitively prove causation.
Limitations in the sensitivity of other tests performed do not completely exclude the potential for other causes.
Attempts to identify EV-F by PCR of paraffin-embedded pulmonary tissue samples obtained from the animals failed, likely due to low RNA quality.

Cite This Study

McClenahan et al. (2013) studied Acute respiratory infection (n=4). Bovine Enterovirus (EV-F) infection was evaluated on Identification of the causative pathogen. A novel bovine enterovirus (Enterovirus F, strain IL/Alpaca) was identified as the potential cause of a fatal acute respiratory infection outbreak in an Illinois alpaca herd.

synapsesocial.com/papers/6a6f5859a528af2d65c2f22d https://doi.org/10.1371/journal.pone.0068777

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