What is the clinical evidence from this study?

Study design: Other. Population: Foot-and-Mouth Disease Virus (FMDV) infection (n=50). Intervention: Direct contact (within-pen) vs. Indirect contact (between-pen). Primary outcome: Daily transmission rate β (number of secondary infections caused by one infectious pig during one day) (p=<0.01).

June 16, 2006Socio-Environmental Systems ModelingOpen Access

Quantification of within- and between-pen transmission of Foot-and-Mouth disease virus in pigs

Q: What are the key findings of this study?

The between-pen transmission rate of Foot-and-Mouth disease virus was 0.59 per day, significantly lower than the within-pen transmission rate of 6.14 per day (p<0.01).

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Key result

The between-pen transmission rate of Foot-and-Mouth disease virus was 0.59 per day, significantly lower than the within-pen transmission rate of 6.14 per day (p<0.01).

Why the study?

Does contact structure influence the transmission rate of Foot-and-Mouth Disease Virus in pigs?

Population

50 pigs

Comparison

Direct contact with FMDV infected pigs vs Indirect contact with FMDV infected pigs

Design

Preclinical

Authors

PEP.L. EbléWageningen University & Research AKAline de KoeijerWageningen University & Research ABA. BoumaMinistry of Agriculture, Nature and Food Quality

Discussion

Member takes

Implication

Pen separation may lower FMDV transmission in pigs; leaves open validation in commercial herds before guiding control policies.

Structured PICO

Does contact structure influence the transmission rate of Foot-and-Mouth Disease Virus in pigs?

Population

50 conventionally reared, six-week-old pigs were studied to quantify the within- and between-pen transmission rates of Foot-and-Mouth disease virus over 14 days.

Exposure

Direct contact with FMDV infected pigs (within-pen)

Comparator

Indirect contact with FMDV infected pigs (between-pen)

Outcome

Daily transmission rate beta (number of secondary infections caused by one infectious pig during one day)surrogate

Main Result

Absolute Event Rate: 6.14% vs 0.59%

p-value: p=<0.01

The transmission rate of Foot-and-Mouth Disease Virus in pigs is significantly influenced by contact structure, with direct contact resulting in a much higher transmission rate than indirect contact.

Limitations

Experimental conditions may not fully replicate field conditions, as parameters like virus strain, infectious dose, and age vary in practice.
Between-pen transmission was only studied in a single group of 10 pigs.
Despite the reduced transmission rate between pens, all contact pigs ultimately became infected.

Cite This Study

Eblé et al. (2006) studied Foot-and-Mouth Disease Virus (FMDV) infection (n=50). Direct contact (within-pen) vs. Indirect contact (between-pen) was evaluated on Daily transmission rate β (number of secondary infections caused by one infectious pig during one day) (p=<0.01). The between-pen transmission rate of Foot-and-Mouth disease virus was 0.59 per day, significantly lower than the within-pen transmission rate of 6.14 per day (p<0.01).

synapsesocial.com/papers/6a6f587f6c240de38cdb7267 https://doi.org/10.1051/vetres:2006026

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June 16, 2006Socio-Environmental Systems ModelingOpen Access

Quantification of within- and between-pen transmission of Foot-and-Mouth disease virus in pigs

View Full Paper

Ask AI

Bookmark

Key result

The between-pen transmission rate of Foot-and-Mouth disease virus was 0.59 per day, significantly lower than the within-pen transmission rate of 6.14 per day (p<0.01).

Why the study?

Does contact structure influence the transmission rate of Foot-and-Mouth Disease Virus in pigs?

Population

50 pigs

Comparison

Direct contact with FMDV infected pigs vs Indirect contact with FMDV infected pigs

Design

Preclinical

Authors

PEP.L. EbléWageningen University & Research AKAline de KoeijerWageningen University & Research ABA. BoumaMinistry of Agriculture, Nature and Food Quality

Discussion

Member takes

Implication

Pen separation may lower FMDV transmission in pigs; leaves open validation in commercial herds before guiding control policies.

Structured PICO

Does contact structure influence the transmission rate of Foot-and-Mouth Disease Virus in pigs?

Population

50 conventionally reared, six-week-old pigs were studied to quantify the within- and between-pen transmission rates of Foot-and-Mouth disease virus over 14 days.

Exposure

Direct contact with FMDV infected pigs (within-pen)

Comparator

Indirect contact with FMDV infected pigs (between-pen)

Outcome

Daily transmission rate beta (number of secondary infections caused by one infectious pig during one day)surrogate

Main Result

Absolute Event Rate: 6.14% vs 0.59%

p-value: p=<0.01

The transmission rate of Foot-and-Mouth Disease Virus in pigs is significantly influenced by contact structure, with direct contact resulting in a much higher transmission rate than indirect contact.

Limitations

Experimental conditions may not fully replicate field conditions, as parameters like virus strain, infectious dose, and age vary in practice.
Between-pen transmission was only studied in a single group of 10 pigs.
Despite the reduced transmission rate between pens, all contact pigs ultimately became infected.

Cite This Study

synapsesocial.com/papers/6a6f587f6c240de38cdb7267 https://doi.org/10.1051/vetres:2006026

Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

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