Key result
Passive immunization with anti-HBcSP55 or anti-HBcSP70 sera protected neonatal mice against lethal EV71 infections through divergent neutralization mechanisms.
Population
Mice (neonatal mice for passive immunization)
Comparison
Chimeric virus-like particles presenting… vs Anti-HBc sera
Design
Preclinical
Authors
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Supports EV71 epitope vaccine development in mice; leaves open human translation and efficacy.
Chimeric VLPs displaying EV71 epitopes SP55 and SP70 elicit protective neutralizing antibodies in mice, representing promising broad-spectrum vaccine candidates.
Ye et al. (2013) studied Enterovirus 71 (EV71) infection. Chimeric virus-like particles (HBcSP55 and HBcSP70) vs. HBc (anti-HBc sera) was evaluated on Protection against lethal EV71 infections and in vitro neutralization. Passive immunization with anti-HBcSP55 or anti-HBcSP70 sera protected neonatal mice against lethal EV71 infections through divergent neutralization mechanisms.
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