February 22, 2013PLoS ONEOpen Access

Neutralizing Antibodies Induced by Recombinant Virus-Like Particles of Enterovirus 71 Genotype C4 Inhibit Infection at Pre- and Post-attachment Steps

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Structured PICO

Population

Mice and in vitro cell models

Intervention

Immunization with recombinant virus-like particles (VLPs) of EV71 genotype C4 and subsequent treatment with anti-VLP mouse sera

Outcome

Neutralization of EV71 infection in vitro (inhibition of virus binding and post-attachment infection)surrogate

Antibodies against EV71 VLPs neutralize infection by inhibiting both pre-attachment and post-attachment steps, informing future vaccine development.

Authors

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Supports conserved epitope targeting for EV71 VLP vaccines; leaves open in vivo protection and human translation.

Ku et al. (2013) studied this question.

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