Key result
Persistent FMDV infection in African buffaloes resulted in an accumulation of low-frequency sequence variants over time, but no evidence of significant antigenic variation leading to immune escape.
Why the study?
It has been proposed that new FMDV variants are produced in African buffalo during prolonged carriage after acute infection and may spread to cause disease in livestock.
Population
African buffalo (Syncerus caffer) with persistent FMDV infection
Authors
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No antigenic escape in persistent buffalo FMDV; leaves open whether carriers drive livestock outbreaks.
Observational
Cortey et al. (2019) conducted an observational in Foot-and-mouth disease virus (FMDV) infection. Persistent FMDV infection was evaluated on Viral evolution and antibody neutralization escape. Persistent FMDV infection in African buffaloes resulted in an accumulation of low-frequency sequence variants over time, but no evidence of significant antigenic variation leading to immune escape.
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