Key result
Experimental FMDV Asia 1 infection in Indian buffaloes induced significant systemic and secretory immune responses but resulted in viral persistence associated with a weak cellular immune response.
In Indian buffaloes, experimental FMDV Asia 1 infection induces significant humoral immunity but weak cellular immunity, leading to viral persistence.
May link weak cellular immunity to FMDV persistence in buffaloes despite humoral responses; leaves open whether T-cell boosting can prevent carriage.
Despite their potential role in the spread of foot-and-mouth disease (FMD), the immune response and viral persistence in FMD virus (FMDV)-infected Indian buffaloes (Bubalus bubalis) have been unexplored. We found similar kinetics of neutralizing antibody responses in the sera and secretory fluids of buffaloes following experimental FMDV Asia 1 infection, but the lymphocyte-proliferative response in infected buffaloes was of low magnitude. Despite inducing a significant systemic and secretory immune response, viral persistence seems to be a common outcome in buffaloes following FMDV Asia 1 infection, which is associated with a weak cellular immune response.
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Maddur et al. (2009) studied Foot-and-mouth disease. Experimental FMDV Asia 1 infection was evaluated on Immune response and viral persistence. Experimental FMDV Asia 1 infection in Indian buffaloes induced significant systemic and secretory immune responses but resulted in viral persistence associated with a weak cellular immune response.
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