Key result
HFMD patients had significantly higher neutralizing antibody titers against EV71 (GMT 72) compared to healthy children (GMT 7.4), though titers did not correlate with disease severity.
Why the study?
What is the neutralizing antibody response to EV71 in HFMD patients compared to healthy controls?
Population
Patients with hand, foot and mouth disease (HFMD) and asymptomatic healthy children and young adults in China
Design
Cohort
Authors
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EV71 titers rise in HFMD without severity correlation; leaves open cellular immunity's role and needs prospective validation.
Observational (n=130)
No
What is the neutralizing antibody response to EV71 in HFMD patients compared to healthy controls?
Absolute Event Rate: 72% vs 7.4%
p-value: p=<0.01
The neutralizing antibody response to EV71 in HFMD patients is rapid but does not correlate with disease severity, suggesting cellular immunity may play a critical role in controlling the infection.
Yang et al. (2011) conducted an observational in Hand, foot and mouth disease (HFMD) (n=130). EV71 infection (HFMD) vs. Asymptomatic healthy children was evaluated on Neutralizing antibody titers against EV71 (Geometric Mean Titer) (p=<0.01). HFMD patients had significantly higher neutralizing antibody titers against EV71 (GMT 72) compared to healthy children (GMT 7.4), though titers did not correlate with disease severity.
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