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8 patients with vaccine-associated paralytic poliomyelitis and 3 wild-type cases; transgenic mice sensitive…
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Stool isolates may misidentify CNS pathogen in VAPP; leaves open reliability of mouse neurovirulence as human surrogate.
Stool isolates may not accurately reflect the etiologic poliovirus strain causing neurological disease in VAPP, and mouse neurovirulence does not perfectly correlate with human neuropathogenicity.
Georgescu et al. (1994) studied this question.
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