Why the study?
Does sudden pulmonary artery constriction affect left ventricular contraction and relaxation in anesthetized open-chest dogs?
Population
Anesthetized open-chest dogs
Comparison
Sudden constriction of the pulmonary artery vs Baseline (prior to constriction)
Design
Preclinical
Follow-up
Immediate (one beat)
Authors
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Acute RV pressure overload alters LV function via direct interaction in dogs; leaves open translation to human biventricular physiology.
Does sudden pulmonary artery constriction affect left ventricular contraction and relaxation in anesthetized open-chest dogs?
Systolic direct ventricular interaction affects left ventricular systolic function and relaxation under normal conditions in the intact circulation.
Slinker et al. (1989) studied this question.
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