August 1, 1983Circulation
Electrophysiologic actions of O-demethyl encainide: an active metabolite.
Why the study?
Does O-demethyl encainide produce electrophysiologic effects similar to prolonged oral encainide therapy in anesthetized dogs?
Population
Anesthetized dogs
Comparison
O-demethyl encainide vs Saline
Design
Preclinical
Authors
Discussion
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Member takes
Implication
May explain route-dependent encainide effects in dogs; hypothesis-generating for human metabolite contributions.
Structured PICO
Does O-demethyl encainide produce electrophysiologic effects similar to prolonged oral encainide therapy in anesthetized dogs?
P
Population
Anesthetized dogs
I
Intervention
O-demethyl encainide (loading and maintenance infusions to produce plasma concentrations similar to those seen during encainide therapy in man: 149 +/- 27 ng/ml and 230 +/- 45 ng/ml)
C
Comparator
Saline
O
Outcome
Electrophysiologic actions (atrial effective refractory period, ventricular refractoriness, AH interval, HV conduction time)surrogate
O-demethyl encainide, an active metabolite of encainide, produces electrophysiologic effects similar to prolonged oral encainide therapy, explaining the disparities between intravenous and oral encainide effects.
Cite This Study
Duff et al. (1983) studied this question.