Population
Normal canine Purkinje fibers and Purkinje fibers surviving 24 h of myocardial ischemia
Design
Preclinical
Authors
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These canine findings should not guide antiarrhythmic use; leaves open metabolite interactions in ischemic conduction.
Encainide and its metabolites have distinct electrophysiological effects on normal versus ischemic canine Purkinje fibers, with the combination of metabolites showing different effects than O-demethyl encainide alone.
Kinnaird et al. (1989) studied this question.
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