Key result
The TCF7L2 rs7903146 minor allele impaired postprandial lipid metabolism, increasing the small-TRL Apo B area under the curve in elderly carriers versus non-carriers (0.72 vs 0.43, p=0.004).
Why the study?
Does the TCF7L2 rs7903146 variation influence postprandial lipid metabolism in healthy young men, metabolic syndrome patients, and healthy elderly persons?
Observational (n=218)
Yes
Does the TCF7L2 rs7903146 variation influence postprandial lipid metabolism in healthy young men, metabolic syndrome patients, and healthy elderly persons?
Absolute Event Rate: 0.72% vs 0.43%
p-value: p=0.004
May indicate genotype-specific postprandial effects in elderly; leaves open relevance to younger adults or metabolic syndrome.
BACKGROUND: TCF7L2 rs7903146 is an important genetic factor predicting type 2 diabetes (T2DM) which has also been linked to higher cardiovascular risk. To date, there is little information about the additional impact of this single nucleotide polymorphism (SNP) beyond glucose metabolism. METHODOLOGY/PRINCIPAL FINDINGS: We studied whether rs7903146 influenced postprandial lipid metabolism in three different populations (healthy young men, metabolic syndrome (MetS) patients and elderly persons). Eighty-eight healthy males were submitted to a single saturated fatty acid-rich test meal. Additionally, 110 middle-aged MetS patients and 20 healthy elderly persons (≥ 65 years) were submitted to three different dietary models followed by test meals. Minor allele homozygotes for rs7903146 showed a worse postprandial lipemia profile in young males, as seen by a lower HDL-cholesterol and Apo A1 concentration during the postprandial lipemia and a trend towards higher triglycerides (TG), than the other genotypes. In healthy elderly persons, carriers of the minor allele showed higher total cholesterol, LDL-cholesterol, Apo B and TG in the fasting state, and a higher postprandial area under the curve for total cholesterol, Apo B, small-triglyceride rich lipoprotein (TRL) cholesterol and small-(TRL) triglycerides. These results were accompanied by differential changes in adipokines. We did not observe any influence of rs7903146 on the postprandium of MetS patients. CONCLUSIONS/SIGNIFICANCE: Healthy young males and elderly persons who are carriers of the mutant allele for rs7903146 have an impaired postprandial lipid metabolism that may be mediated by an alteration in adipokine regulation, and may be related to the higher cardiovascular risk observed in these persons. TRIAL REGISTRATION: ClinicalTrials.gov NCT00429195.
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Pérez‐Martínez et al. (2012) conducted an observational in Healthy subjects and Metabolic Syndrome (n=218). TCF7L2 rs7903146 minor allele vs. TCF7L2 rs7903146 major allele homozygotes (CC) was evaluated on Postprandial area under the curve (AUC) for small-TRL Apo B in elderly persons (p=0.004). The TCF7L2 rs7903146 minor allele impaired postprandial lipid metabolism, increasing the small-TRL Apo B area under the curve in elderly carriers versus non-carriers (0.72 vs 0.43, p=0.004).
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