Key result
The TCF7L2 rs7903146 T-allele was associated with increased peripheral insulin sensitivity in elderly carriers (P=0.03) and impaired hepatic insulin sensitivity in young carriers (P=0.04).
Why the study?
Does the TCF7L2 rs7903146 T-allele affect insulin secretion and action in young and elderly individuals?
Population
783 Danish twins, comprising a population-based sample of 587 twins with glucose tolerance ranging from…
Comparison
TCF7L2 rs7903146 T-allele carrier status vs Non-carriers of the TCF7L2 rs7903146 T-allele
Design
Cross-sectional
Authors
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Age-specific TCF7L2 effects on insulin sensitivity warrant caution in risk interpretation; leaves open mechanistic contributions to diabetes across the lifespan.
Cross-Sectional (n=783)
Does the TCF7L2 rs7903146 T-allele affect insulin secretion and action in young and elderly individuals?
p-value: p=0.03
The TCF7L2 rs7903146 T-allele is associated with hepatic insulin resistance and diminished glucose-stimulated plasma insulin secretion, rather than a defect in peripheral insulin action.
Wegner et al. (2008) conducted a cross-sectional in Glucose tolerance ranging from normal to type 2 diabetes (n=783). TCF7L2 rs7903146 T-allele vs. Non-carriers was evaluated on Insulin secretion and peripheral and hepatic insulin action (p=0.03). The TCF7L2 rs7903146 T-allele was associated with increased peripheral insulin sensitivity in elderly carriers (P=0.03) and impaired hepatic insulin sensitivity in young carriers (P=0.04).
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