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ASHFORD AND HOLMES [1931] found that sodium glycerophosphate increases the oxygen uptake of chopped brain tissue from rabbits, and Davies and Quastel [1932] that it can donate hydrogen to methylene blue in the presence of bullock's brain. In neither of these researches was the isomeride specified. Peters and Sinclair [1933, 1] showed that oc-, but not f-, glycerophosphate in- creases the oxygen uptake of normal pigeon's brain, and [1933, 2] that the effect of pyruvic acid on the extra respiration of the vitamin Bl-deficient brain due to oc-glycerophosphate is apparently inconsistent with the scheme of Embden and Meyerhof. The importance of this scheme as a mechanism for glycolysis justified a study of the metabolism of oc-glycerophosphate in the brain.
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Robert E. Johnson (1936) studied this question.
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