Key result
A 12-month diet rich in resistant starch significantly reduced leptin levels by 13% in obese prediabetic adults, whereas an ordinary fibre diet reduced apelin levels by 21%.
Why the study?
The impact of diet and fibre fractions on adipocytokines in obese individuals at risk for diabetes had not been investigated in detail.
Does a resistant starch-rich fibre diet improve plasma adipocytokine levels compared to an ordinary food fibre diet in obese prediabetic adults?
RCT (n=50)
Does a resistant starch-rich fibre diet improve plasma adipocytokine levels compared to an ordinary food fibre diet in obese prediabetic adults?
Different dietary fibre fractions, specifically resistant starch versus ordinary fibre, differentially modulate adipocytokine profiles such as leptin and apelin in obese prediabetic adults.
May support fibre-type tailoring in prediabetes lifestyle advice; leaves open confirmation in larger trials.
The impact of diet and fibre fractions on adipocytokines in obese subjects with a risk of diabetes has not been investigated in detail yet. The purpose of the study is to evaluate the effects of a 12-month lifestyle intervention with different fibre profiles (resistant starch (RS)-rich fibre, or ordinary food fibre profiles) on adipocytokine levels. Fifty participants are divided into two groups (RS group and Fibre group). The groups differ only in the percentage of the recommended level of the RS consumed as a fraction of the same total fibre amount. The applied dietary intervention includes intake of 7531 KJ/daywith a total fibre portion of 25-35 g/dayfor both groups that includes 15 g/day of RS for the RS group only. The levels of leptin, adiponectin, apelin, resistin, tumor necrosis factor (TNF)-alpha and C-reactive protein (CRP) are measured, and their relationship to anthropometric and biochemical parameters is estimated. Along with significant body weight loss, only leptin is significantly reduced by 13% in the RS group while in the Fibre group, apelin levels are significant (-21%). Polynomial regression shows a negative correlation between RS intake and adiponectin (R2 = 0.145) and resistin level (R2 = 0.461) in the RS group. This study indicates the possibility that fibre fractions differently influence the outcome of lifestyle interventions, as well as their adipocytokine levels, in obese prediabetic adults.
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Dodevska et al. (2021) conducted an RCT in Obese prediabetic adults (n=50). Resistant starch (RS)-rich fibre diet vs. Ordinary food fibre profile (25-35 g/day total fibre and 7531 KJ/day) was evaluated on Adipocytokine levels (leptin, adiponectin, apelin, resistin, TNF-alpha, CRP). A 12-month diet rich in resistant starch significantly reduced leptin levels by 13% in obese prediabetic adults, whereas an ordinary fibre diet reduced apelin levels by 21%.
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