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Tmis paper is concerned with measurements of the rates of acetoacetic acid formation from fatty acids in tissues other than liver. The oxidation of fatty acids in the liver has been dealt with in Parts I and II of this series [Jowett and Quastel, 1935, 1, 2]. The paper also describes the effect of sodium malonate in increasing acetoacetic acid formation in the liver-an effect which is largely due to its inhibitory action on acetoacetic acid breakdown-and the effects of atoxyl and quinine in depressing the " spontaneous " acetoacetic acid formation in this organ. Measurements have been made of the rate of destruction of acetoacetic acid by tissues.
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Jowett et al. (1935) studied this question.
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