Key result
Comparing extreme quartiles, higher relative peak exercise oxygen pulse was associated with a reduced risk of sudden cardiac death (HR 0.55; 95% CI 0.36-0.83; P<0.001) in middle-aged men.
Why the study?
Does higher relative peak exercise oxygen pulse predict reduced sudden cardiac death and mortality in middle-aged men?
Population
2,227 middle-aged men from the Kuopio Ischaemic Heart Disease cohort study
Comparison
Higher relative peak exercise oxygen pulse vs Lower relative peak exercise oxygen pulse
Design
Cohort
Follow-up
median 26.1 years
Authors
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May enhance CPET-based risk stratification; leaves open incremental value over standard measures.
Cohort (n=2,227)
Does higher relative peak exercise oxygen pulse predict reduced sudden cardiac death and mortality in middle-aged men?
Hazard Ratio: 0.55 (95% CI 0.36–0.83)
p-value: p=<0.001
Relative peak exercise oxygen pulse is a strong, independent predictor of sudden cardiac death, cardiovascular mortality, and all-cause mortality in middle-aged men, improving risk discrimination beyond conventional factors.
Laukkanen et al. (2018) reported a cohort. Relative peak exercise oxygen pulse vs. Lowest quartile of relative peak exercise oxygen pulse was evaluated on Sudden cardiac death (HR 0.55, 95% CI 0.36-0.83, p=<0.001). Comparing extreme quartiles, higher relative peak exercise oxygen pulse was associated with a reduced risk of sudden cardiac death (HR 0.55; 95% CI 0.36-0.83; P<0.001) in middle-aged men.
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