May 26, 2007DiabetesOpen Access

High Glucose Impairs Early and Late Endothelial Progenitor Cells by Modifying Nitric Oxide–Related but Not Oxidative Stress–Mediated Mechanisms

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Population

Mononuclear cells isolated from healthy subjects

Comparison

Chronic incubation with high glucose vs Mannitol (osmotic control)

Design

Preclinical

Follow-up

Up to 2-4 weeks

Authors

YCYung‐Hsiang ChenAsia University SLShing‐Jong LinGeneral / Preventive / Lipids FLFeng‐Yen LinNational Yang Ming Chiao Tung University

Discussion

Member takes

Implication

May underlie diabetic vasculopathy; leaves open nitric oxide-targeted EPC restoration in human studies.

Structured PICO

Population

Mononuclear cells isolated from healthy subjects

Intervention

Chronic incubation with high glucose

Comparator

Mannitol (osmotic control)

Outcome

Number and proliferation of early and late endothelial progenitor cells (EPCs)surrogate

High glucose impairs endothelial progenitor cell function via nitric oxide-related mechanisms rather than oxidative stress, highlighting a potential pathway for diabetic vascular complications.

Cite This Study

Chen et al. (2007) studied this question.

synapsesocial.com/papers/6a6f5b76febe604dd7084cdc https://doi.org/10.2337/db06-1103

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