Population
beta1-tubulin-null mice, beta1-tubulin+/- mice, and GATA1-null mice and their derived platelets
Comparison
Genetic deficiency of beta1-tubulin or GATA1 vs Wild-type mice/platelets (implied)
Design
Preclinical
Authors
Loading...
Mouse data indicate discoid shape is dispensable for platelet function under shear; leaves open beta1-tubulin relevance to human hemostasis or therapies.
The MK/platelet-restricted beta1-tubulin isoform is essential for maintaining platelet discoid shape, but spherocytosis does not impair platelet function under physiologic shear conditions.
Italiano et al. (2003) studied this question.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: