Key result
Estimated wall shear stress using plane wave vector Doppler in an in silico phantom agreed within 10% of ground-truth values, with WSS increasing with the degree of stenosis.
Why the study?
Wall shear stress plays an important role in atherosclerotic plaque formation, growth, and rupture, requiring validation of plane wave vector Doppler for its measurement across varying degrees of stenosis.
Does plane wave vector Doppler accurately measure wall shear stress in carotid artery phantoms with varying degrees of stenosis?
Does plane wave vector Doppler accurately measure wall shear stress in carotid artery phantoms with varying degrees of stenosis?
Plane wave vector Doppler provides accurate wall shear stress measurements in carotid artery phantoms, supporting its potential clinical application for assessing atherosclerotic plaque vulnerability.
Enables WSS estimation in carotid phantoms via PW vector Doppler; leaves open clinical translation and plaque risk assessment.
Wall shear stress (WSS) plays an important role in the formation, growth, and rupture of atherosclerotic plaques in arteries. This study measured WSS in diseased carotid artery phantoms with degrees of stenosis varying from 0 to 60% with both steady and pulsatile flow. Experiments were performed using in silico and real flow phantoms. Blood velocities were estimated using plane wave (PW) vector Doppler. Wall shear stress was then estimated from the velocity gradient near the wall multiplied by the viscosity of a blood-mimicking fluid. The estimated WSS using the in silico phantom agreed within 10% of the ground-truth values (root-mean-square error). The phantom experiment showed that the mean WSS and maximum WSS increased with the increasing degree of stenosis. The simulation and experiment results provide the necessary validation data to give confidence in WSS measurements in patients using the PW vector Doppler technique.
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Yang et al. (2023) studied Carotid artery stenosis (simulated). Plane wave vector Doppler vs. Ground-truth values (in silico) was evaluated on Wall shear stress (WSS) estimation accuracy. Estimated wall shear stress using plane wave vector Doppler in an in silico phantom agreed within 10% of ground-truth values, with WSS increasing with the degree of stenosis.
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