Key result
Dynamic wall shear stress mapping using ultrafast ultrasound vector Doppler successfully measured time-averaged WSS in the femoral arteries of healthy volunteers.
Why the study?
Achieving reliable, noninvasive wall shear stress mapping of an artery using existing imaging modalities remains challenging.
Can wall shear stress mapping based on ultrafast ultrasound vector Doppler estimations accurately measure dynamic WSS in the human femoral artery?
Observational (n=5)
Can wall shear stress mapping based on ultrafast ultrasound vector Doppler estimations accurately measure dynamic WSS in the human femoral artery?
Ultrafast ultrasound vector Doppler estimation is a feasible noninvasive tool for dynamic wall shear stress mapping in the human femoral artery.
Demonstrates the feasibility of non-invasive wall shear stress assessment; leaves open whether this ultrasound technique.
PURPOSE: Wall shear stress (WSS), a type of friction exerted on the artery wall by flowing blood, is considered a crucial factor in atherosclerotic plaque development. Currently, achieving a reliable WSS mapping of an artery noninvasively by using existing imaging modalities is still challenging. In this study, a WSS mapping based on vector Doppler flow velocity estimation was proposed to measure the dynamic WSS on the human femoral artery. METHODS: Because ultrafast ultrasound imaging was used here, flow-enhanced imaging was also performed to observe the moving blood flow condition. The performance of WSS mapping was verified using both straight (8 mm in diameter) and stenosis (70% of stenosis) phantoms under a pulsatile flow condition. A human study was conducted from five healthy volunteers. RESULTS: Experimental results demonstrated that the WSS estimation was close to the standard value that was obtained from maximum velocity estimation in straight phantom experiments. In a stenosis phantom experiment, a low WSS region was observed at a site downstream of an obstruction, which is a high-risk area for plaque formation. Dynamic WSS mapping was accomplished in measurement in the femoral artery bifurcation. In measurements, the time-averaged WSS of the common femoral artery, superficial femoral artery, and deep femoral artery was 0.52± 0.19, 0.44 ± 0.21, and 0.29 ± 0.16 Pa, respectively, for the anterior wall and 0.29 ± 0.11, 0.54 ± 0.24, and 0.23 ± 0.10 Pa, respectively, for the posterior wall. CONCLUSIONS: All results indicated that WSS mapping has the potential to be a useful tool for vessel duplex scanning in the future.
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Wang et al. (2021) conducted an observational in Healthy (n=5). Wall shear stress mapping based on ultrafast ultrasound vector Doppler was evaluated on Time-averaged wall shear stress (WSS). Dynamic wall shear stress mapping using ultrafast ultrasound vector Doppler successfully measured time-averaged WSS in the femoral arteries of healthy volunteers.
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