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January 1, 2014Thrombosis and Haemostasis

Organ-specific bleeding patterns of anticoagulant therapy: lessons from clinical trials

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Why the study?

Do NOACs alter organ-specific bleeding patterns compared to VKAs in patients with non-valvular atrial fibrillation?

Population

Patients with non-valvular atrial fibrillation (AF)

Comparison

Non-VKA oral anticoagulants (NOACs) vs Vitamin K antagonists (VKAs) such as warfarin

Design

Review

Authors

TVThomas VanasscheJHJack HirshJGJeffrey S. Ginsberg

Discussion

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Overview

Supports NOAC use in NVAF for lower ICH risk; confirms efficacy parity but leaves GI bleeding agent-specific questions open.

Structured PICO

Do NOACs alter organ-specific bleeding patterns compared to VKAs in patients with non-valvular atrial fibrillation?

P
Population
Patients with non-valvular atrial fibrillation (AF)
I
Intervention
Non-VKA oral anticoagulants (NOACs)
C
Comparator
Vitamin K antagonists (VKAs) such as warfarin
O
Outcome
Organ-specific bleeding patterns (major bleeding, intracranial hemorrhage, gastro-intestinal bleeding)safety

NOACs provide similar efficacy to warfarin in non-valvular AF but present a distinct organ-specific bleeding profile, notably reducing intracranial hemorrhage while potentially increasing gastrointestinal bleeding.

Cite This Study

Vanassche et al. (2014) studied this question.

synapsesocial.com/papers/6a6f5d0ca528af2d65c2f3f4https://doi.org/10.1160/th14-04-0346
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