Why the study?
Does a high-methionine diet inducing hyperhomocysteinemia increase monocyte adhesion to aortic endothelium in Sprague-Dawley rats?
Does a high-methionine diet inducing hyperhomocysteinemia increase monocyte adhesion to aortic endothelium in Sprague-Dawley rats?
Hyperhomocysteinemia induced by a high-methionine diet stimulates the expression of MCP-1, VCAM-1, and E-selectin in vivo, leading to increased monocyte adhesion to the aortic endothelium and impaired vasorelaxation.
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Hypothesis-generating for hyperhomocysteinemia-driven endothelial inflammation; leaves open human translation and clinical relevance.
Wang et al. (2002) studied this question.
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