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March 1, 1968The Journal of General PhysiologyOpen Access

Electrical Transmission at the Nexus between Smooth Muscle Cells

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Population

Smooth muscle preparations from the taenia coli of guinea pigs

Comparison

Application of hypertonic solutions and… vs Baseline/normal conditions

Design

Preclinical

Authors

LBLloyd BarrUniversity of LancashireWBW. BergerUniversity of MiamiMDMaynard M. DeweyTufts University

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Implication

Nexus-dependent electrical coupling in smooth muscle is confirmed in animals; human relevance and therapeutic implications remain untested.

Structured PICO

P
Population
Smooth muscle preparations from the taenia coli of guinea pigs
I
Intervention
Application of hypertonic solutions and connection of a shunt resistor across a sucrose gap
C
Comparator
Baseline/normal conditions
O
Outcome
Action potential propagation and electrical resistance across the sucrose gapsurrogate

Demonstrates that transmission between smooth muscle cells is electrical and depends on intact nexuses, which are structurally and functionally disrupted by hypertonicity.

Cite This Study

Barr et al. (1968) studied this question.

synapsesocial.com/papers/6a6f5fc2c92390ac2d079aa1https://doi.org/10.1085/jgp.51.3.347
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Intracellular and external recording from frog ventricular fibers during hypertonic perfusion1960 · 42 citations
  2. 2Propagation of Action Potentials and the Structure of the Nexus in Cardiac Muscle1965 · 466 citations
  3. 3Electrical parameters of smooth muscle cells1963 · 73 citations
  4. 4Transmembrane resistance of smooth muscle cells1961 · 20 citations