Key result
Salusin-α levels were negatively correlated with diastolic blood pressure (r = 0.277, p = 0.004), although overall levels did not differ significantly between obese and healthy children.
Why the study?
Salusins have emerged as a new biomarker reflecting an increased inflammatory state associated with cardiovascular risk, but their predictive value and usefulness in obese children remained uninvestigated.
Are Salusin-α and Salusin-β levels associated with cardiovascular parameters in obese children compared to healthy controls?
Cohort (n=176)
Are Salusin-α and Salusin-β levels associated with cardiovascular parameters in obese children compared to healthy controls?
Effect estimate: r = 0.277
p-value: p=0.004
Salusin-α levels are negatively correlated with diastolic blood pressure in obese children, suggesting it may serve as an early marker of cardiovascular involvement.
Salusins were associated with cardiovascular parameters in obese children; leaves open their predictive value as biomarkers.
Salusins have emerged as a new biomarker that reflects an increased inflammatory state, which is associated with cardiovascular risk. We investigated the predictive value and usefulness of salusins as an inflammatory biomarker in obese children. This prospective cohort study included 75 obese children and 101 healthy children (as a control group). Salusin-α, Salusin-β, and various cardiovascular parameters were assessed in both groups. Correlation analyses of Salusin-α and Salusin-β with body mass index standard deviation scores and inflammatory and cardiovascular markers were performed. The mean patient age was 11.9±2.4 years for the obese group and 12.5±2.1 years for the control group. The obese children had a significantly higher heart rate, systolic blood pressure, diastolic blood pressure, epicardial adipose tissue thickness, and left ventricular mass than did the children in the control group. There was no significant correlation between Salusin-α and Salusin-β and body mass index; however, there was a negative correlation between Salusin- α and diastolic blood pressure (r = 0.277, p = 0.004). Overall, there was no significant difference in the Salusin-α and Salusin-β levels between obese and healthy children. However, a negative correlation was found between Salusin-α and diastolic blood pressure. Although this result suggests that Salusin-α might be an early marker of cardiovascular involvement in obese children, further studies are needed to demonstrate the predictive value of salusins.
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Dervişoğlu et al. (2019) conducted a cohort in Obesity (n=176). Obesity vs. Healthy children was evaluated on Correlation between Salusin-α and diastolic blood pressure (r = 0.277, p=0.004). Salusin-α levels were negatively correlated with diastolic blood pressure (r = 0.277, p = 0.004), although overall levels did not differ significantly between obese and healthy children.
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