This preclinical study identifies distinct muscle-derived factors that enhance skeletal muscle glucose uptake and cardiac contractility.
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Does not support clinical adoption; leaves open distinct myokine roles in human glucose uptake and cardiac contractility.
A material has been isolated from the incubation medium of both resting and stimulated rat hemidiaphragms and tested for cardiac inotropic activity as well as for ability to enhance sugar uptake by skeletal muscle. It appears that a factor which increases glucose uptake is released from contracting muscle only, whereas a factor which increases the force of contraction of isolated failed atria is released both by contracting muscle and by muscle at rest.
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Frederickson et al. (1969) studied this question.
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