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August 1, 2020Physiological ReportsOpen Access

Circulating microparticle concentrations across acute and chronic cardiovascular disease conditions

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Why the study?

Concentrations of different circulating microparticles may have clinical and physiological relevance to cardiovascular disease pathologies.

Do plasma concentrations of specific microparticles differ between healthy older men and those with CAD or NSTEMI?

Population

CAD patients (n = 10), NSTEMI patients (n = 13), and healthy older men (n = 15) 60-75 years old

Comparison

CAD vs NSTEMI vs healthy older controls

Design

Cross-sectional comparative study

Authors

RLRian Q. Landers‐RamosTowson UniversityOAOdessa AddisonUniversity of Maryland, BaltimoreBBBrock A. BeamerUniversity of Maryland, Baltimore

Discussion

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Implication

Differential MP levels across CAD stages; hypothesis-generating for biomarker potential, larger prospective studies needed.

Structured PICO

Do plasma concentrations of specific microparticles differ between healthy older men and those with CAD or NSTEMI?

P
Population
38 men aged 60-75 years old, including CAD patients (n=10), NSTEMI patients (n=13), and healthy older men (n=15).
C
Comparator
Healthy older men (n=15)
O
Outcome
Plasma concentrations of CD31+/CD42b-, CD62E+, and CD34+ microparticlessurrogate

CD31+/CD42b- microparticles are significantly lower in patients with CAD and NSTEMI compared to healthy individuals, suggesting potential utility as a cardiovascular biomarker.

Cite This Study

Landers‐Ramos et al. (2020) studied this question.

synapsesocial.com/papers/6a6f61676c240de38cdb7477https://doi.org/10.14814/phy2.14534

Topics

Coronary artery disease
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