November 28, 2005Proceedings of the National Academy of SciencesOpen Access

Mutation in sodium–calcium exchanger 1 (NCX1) causes cardiac fibrillation in zebrafish

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Why the study?

Does forced expression of NCX1h restore synchronized heartbeats in zebrafish tremblor mutants?

Population

Zebrafish tremblor (tre) mutant embryos

Comparison

Forced expression of NCX1h or other… vs Untreated tre mutant embryos

Design

Preclinical

Authors

ALAdam D. LangenbacherUniversity of California, Los Angeles YDYuandan DongUniversity of Electronic Science and Technology of China XSXiaodong ShuZhejiang University of Science and Technology

Discussion

Member takes

Implication

May guide calcium-handling therapies in arrhythmia models; leaves open translation to human disease.

Structured PICO

Does forced expression of NCX1h restore synchronized heartbeats in zebrafish tremblor mutants?

Population

Zebrafish tremblor (tre) mutant embryos

Intervention

Forced expression of NCX1h or other calcium-handling molecules

Comparator

Untreated tre mutant embryos

Outcome

Restoration of synchronized heartbeats and calcium transientssurrogate

This preclinical study demonstrates the essential role of the sodium-calcium exchanger NCX1h and calcium homeostasis in establishing rhythmic contraction in the embryonic zebrafish heart.

Cite This Study

Langenbacher et al. (2005) studied this question.

synapsesocial.com/papers/6a6f6370439bab0cabc2c626 https://doi.org/10.1073/pnas.0502679102

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Mutation in sodium–calcium exchanger 1 (NCX1) causes cardiac fibrillation in zebrafish

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Mutation in sodium–calcium exchanger 1 (NCX1) causes cardiac fibrillation in zebrafish

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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