Population
Embryonic zebrafish, including wild-type and tremblor (tre) mutants (NCX1h mutants)
Comparison
Mutation of NCX1h, morpholino-mediated knockdown… vs Wild-type sibling embryos or DMSO-treated…
Design
Preclinical
Follow-up
up to 6 days postfertilization
Authors
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NCX1h and SERCA2 differentially regulate embryonic cardiac rhythm; leaves open whether selective targeting prevents congenital arrhythmias.
Inhibition of NCX1h versus SERCA2 activity differentially affects the pathophysiology of rhythm in the developing heart, highlighting their distinct essential roles in normal cardiac development.
Ebert et al. (2005) studied this question.
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