What question did this study set out to answer?

To outline the biochemical architecture and conserved biological functions of the Hippo signaling cascade in directing organ size, tissue development, and cell fate determination.

June 1, 1985Annual Review of Biochemistry

Time-Resolved Fluorescence of Proteins

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Authors

JBJoseph BeechemBruker (United States)LBLudwig BrandJohns Hopkins University

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Implication

Molecular analysis reveals conserved Hippo signaling mechanisms governing cell growth across organisms, highlighting regulatory controls over organ development.

Key Points

To outline the biochemical architecture and conserved biological functions of the Hippo signaling cascade in directing organ size, tissue development, and cell fate determination.
Reviewed genetic and molecular evidence characterizing the Hippo signaling pathway originally identified in Drosophila melanogaster.
Assessed protein-level dynamics and biochemical cascade components regulating cell proliferation and physiological tissue growth.
Hippo signaling functions as an evolutionarily conserved cascade that governs organ dimensions and determines cell lineage commitments across species.
Disruption of pathway signaling components alters biological coordination of cell proliferation and developmental tissue growth control.

Cite This Study

Beechem et al. (1985) studied this question.

synapsesocial.com/papers/6a6f640d2163a0a01bc3b147 https://doi.org/10.1146/annurev.bi.54.070185.000355

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Implication

Molecular analysis reveals conserved Hippo signaling mechanisms governing cell growth across organisms, highlighting regulatory controls over organ development.

Time-Resolved Fluorescence of Proteins

Discussion

Member takes

Implication

Key Points

Cite This Study

Time-Resolved Fluorescence of Proteins

Discussion

Member takes

Implication

Key Points

Cite This Study

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