Why the study?
Does CRT-D improve overall survival in heart failure patients with varying degrees of renal insufficiency compared to standard defibrillators?
Population
875 heart failure patients meeting clinical criteria for CRT-D, with glomerular filtration rate measured…
Comparison
Cardiac resynchronization therapy-defibrillator vs Standard defibrillator placed after unsuccessful…
Design
Cohort
Authors
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CRT-D was associated with better survival in moderate renal insufficiency; leaves open whether benefit extends across GFR strata and requires randomized confirmation.
Does CRT-D improve overall survival in heart failure patients with varying degrees of renal insufficiency compared to standard defibrillators?
CRT-D provides a significant survival benefit in heart failure patients with moderate renal insufficiency, but may not offer an overall survival advantage over standard defibrillators in those with severe renal insufficiency or normal renal function.
Adelstein et al. (2010) studied this question.
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