Why the study?
Endothelial dysfunction predicts cardiovascular events and initiates atherosclerosis, prompting interest in the molecular mechanisms underlying the vascular benefits of chlorogenic acid.
Does chlorogenic acid improve vascular health and prevent cardiovascular events?
Does chlorogenic acid improve vascular health and prevent cardiovascular events?
Chlorogenic acid, a primary polyphenol in coffee, exhibits multiple cardiovascular protective effects including anti-atherosclerotic, anti-thrombotic, and anti-hypertensive properties via various molecular pathways.
Vascular endothelial cells have a variety of functions such as the control of blood coagulation, vascular permeability, and tone regulation, as well as quiesce of immune cells. Endothelial dysfunction is a cardiovascular events predictor, which is considered the initial stage in atherosclerosis development. It is characterized by alterations in endothelium functions due to imbalanced vasodilators and vasoconstrictors, procoagulant and anticoagulant mediators, as well as growth inhibitor and promotor substances. Chlorogenic acid (CGA) is the primary polyphenol in coffee and some fruits. It has many health-promoting properties, especially in the cardiovascular system. Many studies investigated the efficacy and mechanism of this compound in vascular health. CGA has several vascular benefits such as anti-atherosclerosis, anti-thrombosis, and anti-hypertensive. This review focuses on the molecular mechanism of CGA in vascular health.
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Lukitasari et al. (2020) studied this question.
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