July 1, 2011PLoS ONEOpen Access

Display of VP1 on the Surface of Baculovirus and Its Immunogenicity against Heterologous Human Enterovirus 71 Strains in Mice

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Population

4-week old female BALB/c mice (n=30)

Comparison

Bac-Pie1-gp64-VP1, 10^8 pfu subcutaneously on… vs Inactivated EV71, wild-type baculovirus Bac-wt…

Design

Preclinical

Follow-up

56 days

Authors

TMTao MengTemasek Life Sciences Laboratory AKAnnasaheb KolpeHester TKTanja K. KienerTemasek Life Sciences Laboratory

Discussion

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Implication

Supports baculovirus VP1 as EV71 vaccine candidate in mice; leaves open translation to human trials.

Structured PICO

Population

4-week old female BALB/c mice (n=30)

Intervention

Bac-Pie1-gp64-VP1 (recombinant baculovirus expressing EV71 VP1), 10^8 pfu subcutaneously on day 0 and day 21

Comparator

Inactivated EV71 (positive control), wild-type baculovirus Bac-wt (negative control), RD cell lysate (negative control), or Bac-Pph-gp64-VP1

Outcome

Neutralization antibody titer against EV71surrogate

Baculovirus-surface displayed VP1 acts as an effective EV71 vaccine candidate in mice, eliciting cross-neutralizing antibodies against multiple EV71 strains.

Cite This Study

Meng et al. (2011) studied this question.

synapsesocial.com/papers/6a6f6891ac440176ef281701 https://doi.org/10.1371/journal.pone.0021757

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Display of VP1 on the Surface of Baculovirus and Its Immunogenicity against Heterologous Human Enterovirus 71 Strains in Mice

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Display of VP1 on the Surface of Baculovirus and Its Immunogenicity against Heterologous Human Enterovirus 71 Strains in Mice

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider