Why the study?
Does intravenous 5-fluorouracil cause ischaemic chest pain?
Does intravenous 5-fluorouracil cause ischaemic chest pain?
Intravenous 5-fluorouracil can cause ischaemic chest pain, a rare but important cardiotoxic complication that may be associated with prior left ventricular irradiation.
Answers are grounded in this paper and cite their sources.
May warrant monitoring for chest pain with 5-FU; leaves open prior LV irradiation link and requires prospective studies.
Our of 140 patients treated with intravenous 5-fluorouracil, four developed ischaemic chest pain within 18 hours of either the second or third dose. In three of these patients the pain recurred after subsequent doses. Predose electrocardiograms in two cases were normal. None of the four patients had a history of ischaemic heart disease, although all had received left ventricular irradiation. Although cardiotoxicity is a rare complication of fluorouracil treatment, it merits wider recognition.
No takes yet. Share an insight, caveat, or question.
Pottage et al. (1978) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: