Why the study?
Does multiple drug treatment with fluorouracil, vincristine, and CCNU cause cardiotoxicity in a patient with large bowel cancer?
Population
A patient with large bowel cancer without any precedent history of heart disease (n=1)
Design
Case_report
Authors
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May signal 5-FU cardiotoxicity risk even without prior heart disease; leaves open causality and generalizability from single case.
Does multiple drug treatment with fluorouracil, vincristine, and CCNU cause cardiotoxicity in a patient with large bowel cancer?
5-fluorouracil-based chemotherapy can induce cardiotoxicity, presenting as chest pain and ECG changes, even in patients without prior heart disease.
Gamucci et al. (1980) studied this question.
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