Population
SH-SY5Y neuroblastoma cells
Comparison
Oxotremorine-M under hypo-osmotic conditions vs Isotonic conditions or absence of oxotremorine-M
Design
Preclinical
Follow-up
up to 4 hours
Authors
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Hypothesis-generating for muscarinic modulation of volume-sensitive efflux; leaves open relevance to human disease or in vivo models.
Activation of muscarinic cholinergic receptors enhances volume-sensitive myo-inositol efflux in SH-SY5Y neuroblastoma cells via calcium and protein kinase C pathways.
Loveday et al. (2003) studied this question.
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