Population
Smooth muscle fragments from the longitudinal layer of the small intestine of the guinea-pig
Comparison
Caffeine, isoprenaline, dibutyryl cyclic AMP… vs Basal conditions or carbachol (CCh) alone
Design
Preclinical
Authors
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Findings in guinea-pig smooth muscle should not inform clinical GI therapy; leaves open caffeine and cAMP effects on muscarinic inositol signaling in humans.
In guinea-pig intestinal smooth muscle, muscarinic receptor-induced inositol phospholipid hydrolysis is inhibited by caffeine, beta-adrenoceptor activation, and protein kinase C.
Prestwich et al. (1995) studied this question.
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