Why the study?
The extent of cytokine changes and their impact on metabolic improvements after bariatric surgery had not been fully explored.
Does bariatric surgery alter circulating cytokines, chemokines, and secreted cytokine receptors in patients with obesity?
Population
37 patients with obesity and 37 lean patients, plus 25 obese patients after bariatric surgery
Comparison
Patients with obesity vs lean patients, and before vs after bariatric surgery
Design
Cross-sectional and prospective cohort study at an academic medical center
Authors
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Cytokine shifts in obesity may mark inflammation; leaves open whether they drive or merely track bariatric surgery metabolic gains.
Does bariatric surgery alter circulating cytokines, chemokines, and secreted cytokine receptors in patients with obesity?
Bariatric surgery shifts the pro-inflammatory cytokine profile of patients with obesity toward that of lean controls, which may contribute to observed metabolic improvements.
Wolf et al. (2018) studied this question.
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