Population
Platelets (in vitro model)
Comparison
Cilostazol vs EHNA, dipyridamole and zaprinast
Design
Preclinical
Authors
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Hypothesis-generating for cilostazol's PDE3-selective platelet effects in animals; leaves open human translation and clinical relevance.
Cilostazol induces VASP phosphorylation in platelets via PDE3 inhibition, cAMP elevation, and PKA activation.
Sudo et al. (2003) studied this question.
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