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February 27, 2015Journal of Cellular Physiology

Silencing Angiopoietin‐Like Protein 4 (ANGPTL4) Protects Against Lipopolysaccharide‐Induced Acute Lung Injury Via Regulating SIRT1 /NF‐kB Pathway

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Why the study?

Does silencing ANGPTL4 protect against LPS-induced acute lung injury in preclinical models?

Population

Mouse model of lipopolysaccharide-induced acute lung injury and human alveolar epithelial A549 cells

Comparison

Lentivirus-mediated short interfering RNA… vs Negative control lentivirus (NCsiRNA)

Design

Preclinical

Authors

LGLiang GuoSLShaoying LiYZYunfeng Zhao

Discussion

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Overview

Supports ANGPTL4 silencing in preclinical ALI models; leaves open translation to human therapy.

Structured PICO

Does silencing ANGPTL4 protect against LPS-induced acute lung injury in preclinical models?

P
Population
Mouse model of lipopolysaccharide (LPS)-induced acute lung injury (ALI) and human alveolar epithelial A549 cells
I
Intervention
Lentivirus-mediated short interfering RNA targeted to the mouse angptl4 gene (AngsiRNA) administered intranasally
C
Comparator
Negative control lentivirus (NCsiRNA)
O
Outcome
Lung inflammatory injury (neutrophils infiltration, TNF-α, IL-6), lung permeability (wet/dry weight ratio, BALF protein concentration), tissue damage (caspase3 activation), and mortality ratessurrogate

Silencing ANGPTL4 protects against LPS-induced acute lung injury by regulating the SIRT1/NF-kB signaling pathway in preclinical models.

Cite This Study

Guo et al. (2015) studied this question.

synapsesocial.com/papers/6a6f6dee31a3df824327cd29https://doi.org/10.1002/jcp.24969
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Also Consider

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  3. 3Multiple anti‐inflammatory pathways triggered by resveratrol lead to amelioration of staphylococcal enterotoxin B‐induced lung injury2012 · 88 citations