September 2, 2002The Journal of Experimental MedicineOpen Access

The Lectin-like Domain of Thrombomodulin Confers Protection from Neutrophil-mediated Tissue Damage by Suppressing Adhesion Molecule Expression via Nuclear Factor κB and Mitogen-activated Protein Kinase Pathways

View Full Paper

Ask AI

Bookmark

Population

Transgenic mice lacking the lectin-like domain of thrombomodulin (TM(LeD/LeD)) and endothelial cells

Design

Preclinical

Authors

ECEdward M. ConwayUniversity of British Columbia MWMarlies Van de WouwerKU Leuven SPSaskia PollefeytTransgene (France)

Discussion

Member takes

Implication

Supports anti-inflammatory role of thrombomodulin lectin domain; hypothesis-generating for human sepsis or MI therapies.

Structured PICO

Population

Transgenic mice lacking the lectin-like domain of thrombomodulin (TM(LeD/LeD)) and endothelial cells

Intervention

Deletion of the lectin-like domain of thrombomodulin (in vivo) and administration of recombinant lectin-like domain of thrombomodulin (in vitro)

Outcome

Survival after endotoxin exposure, PMN accumulation in lungs, infarct size after myocardial ischemia/reperfusion, and PMN adhesion to endothelial cells

The lectin-like domain of thrombomodulin exhibits anti-inflammatory properties that protect against neutrophil-mediated tissue damage and reduce infarct size after myocardial ischemia/reperfusion.

Cite This Study

Conway et al. (2002) studied this question.

synapsesocial.com/papers/6a6f6df231a3df824327cd50 https://doi.org/10.1084/jem.20020077

View Full Paper

Ask AI

Bookmark

The Lectin-like Domain of Thrombomodulin Confers Protection from Neutrophil-mediated Tissue Damage by Suppressing Adhesion Molecule Expression via Nuclear Factor κB and Mitogen-activated Protein Kinase Pathways

Discussion

Member takes

Implication

Structured PICO

Cite This Study

The Lectin-like Domain of Thrombomodulin Confers Protection from Neutrophil-mediated Tissue Damage by Suppressing Adhesion Molecule Expression via Nuclear Factor κB and Mitogen-activated Protein Kinase Pathways

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider