Population
COS cells transfected with different truncated forms of Thrombomodulin (TM)
Comparison
Expression of truncated forms of TM lacking… vs Wild-type TM-transfected COS cells
Design
Preclinical
Authors
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TM lectin-like domain enables endocytosis in cell models; leaves open its role regulating thrombin in vivo.
The lectin-like domain of human thrombomodulin is required for its constitutive endocytosis, suggesting a role in regulating cell surface expression and controlling thrombin accumulation.
Conway et al. (1997) studied this question.
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